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Soundbite Medical’s Directional Intravascular Lithotripsy Solution

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The use of shock waves to treat calcium deposits, also known as lithotripsy, is a proven, powerful tool used by clinicians in patients across multiple clinical applications. Soundbite Medical has developed a unique platform for generating and delivering shock waves to vascular calcific lesions.

Soundbite’s Unique Mechanism of Action


Multiple, small amplitude mechanical shock waves are created outside of the body in the console


By adjusting the timing of the shock waves, they combine into one single, larger amplitude shock wave


The single shock wave is delivered via an “Active” Waveguide Platform to the lesion inside the artery


As the shock wave leaves the waveguide, the resulting tip motion creates a micro jackhammer effect with the wire and the shock wave propagates and selectively penetrates and cracks the hard, calcific plaque while passing through the soft tissue

An example of how the shock wave propagates along the waveguide

Shock wave energy creates a hole in the “hard shell” of the egg…

…but is safe on soft tissue

SoundBite Active Wire unable to cross until “activated”

SoundBite XS Crossing System

It is designed to deliver shock waves to create a channel through the calcific cap or other calcified refractory barriers within a CTO. The Active Wire is inserted into the arterial vasculature via standard minimally invasive access technique. The SoundBite XS Crossing System facilitates intraluminal placement of conventional guidewires or treatment devices beyond the peripheral arterial CTO.

XS Console

Generates the Shock Waves

  • Mobile, non-sterile, reusable
  • Intuitive, easy-to-use interface

Active Wire XS 14P

Waveguide that Delivers IVL to Lesion

  • Sterile, single-use
  • Specifications: 0.014” max outer diameter over usable length, 175cm usable length
  • Accessories – disposable accessories to assist in crossing


Side-mounted torquing device to provide gripping surface during handling

  • Sterile, single-use device
  • Used with physician discretion

Curving Tool

Provides Different Curve
Options for Wire Tip

  • Sterile, single-use
  • Used to create a short or long gradual curve on distal tip of the Active Wire XS 14P
  • Used with physician discretion

Breaking New Ground with Active Wire

Promising Early Performance in Highly Calcified Lower Extremity CTOs

We are committed to building our clinical evidence with our devices in support of better utilization and procedure results and outcomes for patients suffering from calcific occlusive cardiovascular disease.


Prospective, multi-center, single-arm pivotal study in Europe and Canada.

Ongoing Clinical Trials

CaTO PAD – Currently Enrolling

Prospective, multi-center, non-randomized, clinical study evaluating the performance of the SoundBite XS Crossing System-14P in the US and Europe.

Learn More

To learn more, review publications.

A Multinational, Single-Arm Pivotal Study Assessing the Performance of the SoundBite Crossing System for Peripheral Chronic Total Occlusions (The PROSPECTOR Study)

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Recanalization of CTOs with SoundBite Active Wire

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Novel Crossing System for the Recanalization of Complex Chronic Total Occlusions: Ex vivo Proof of Concept of the SoundBite Crossing System.

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Novel Crossing System for Chronic Total Occlusion Recanalization: First-in-Man Experience With the SoundBite Crossing System

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  1. Therasse, E. et al. A Multinational, Single-Arm Pivotal Study Assessing the Performance of the SoundBite Crossing System for Peripheral Chronic Total Occlusions (The PROSPECTOR Study), J Vasc Interv Radiol. 2022; 33:50-59.
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